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Anti-influenza H7 human antibody targets antigenic site in hemagglutinin head domain interface.


ABSTRACT: Although broadly protective, stem-targeted Abs against the influenza A virus hemagglutinin (HA) have been well studied, very limited information is available on Abs that broadly recognize the head domain. We determined the crystal structure of the HA protein of the avian H7N9 influenza virus in complex with a pan-H7, non-neutralizing, protective human Ab. The structure revealed a B cell epitope in the HA head domain trimer interface (TI). This discovery of a second major protective TI epitope supports a model in which uncleaved HA trimers exist on the surface of infected cells in a highly dynamic state that exposes hidden HA head domain features.

SUBMITTER: Dong J 

PROVIDER: S-EPMC7456233 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Anti-influenza H7 human antibody targets antigenic site in hemagglutinin head domain interface.

Dong Jinhui J   Gilchuk Iuliia I   Li Sheng S   Irving Ryan R   Goff Matthew T MT   Turner Hannah L HL   Ward Andrew B AB   Carnahan Robert H RH   Crowe James E JE  

The Journal of clinical investigation 20200901 9


Although broadly protective, stem-targeted Abs against the influenza A virus hemagglutinin (HA) have been well studied, very limited information is available on Abs that broadly recognize the head domain. We determined the crystal structure of the HA protein of the avian H7N9 influenza virus in complex with a pan-H7, non-neutralizing, protective human Ab. The structure revealed a B cell epitope in the HA head domain trimer interface (TI). This discovery of a second major protective TI epitope su  ...[more]

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