Ontology highlight
ABSTRACT:
SUBMITTER: Xiong X
PROVIDER: S-EPMC5536957 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Xiong Xiong X Zhang Yanxiao Y Yan Jian J Jain Surbhi S Chee Sora S Ren Bing B Zhao Huimin H
ACS synthetic biology 20170307 6
Eukaryotic transcriptional factors (TFs) typically recognize short genomic sequences alone or together with other proteins to modulate gene expression. Mapping of TF-DNA interactions in the genome is crucial for understanding the gene regulatory programs in cells. While chromatin immunoprecipitation followed by sequencing (ChIP-Seq) is commonly used for this purpose, its application is severely limited by the availability of suitable antibodies for TFs. To overcome this limitation, we developed ...[more]