Ontology highlight
ABSTRACT:
SUBMITTER: Polonchuk L
PROVIDER: S-EPMC5539326 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Polonchuk Liudmila L Chabria Mamta M Badi Laura L Hoflack Jean-Christophe JC Figtree Gemma G Davies Michael J MJ Gentile Carmine C
Scientific reports 20170801 1
Three-dimensional in vitro cell systems are a promising alternative to animals to study cardiac biology and disease. We have generated three-dimensional in vitro models of the human heart ("cardiac spheroids", CSs) by co-culturing human primary or iPSC-derived cardiomyocytes, endothelial cells and fibroblasts at ratios approximating those present in vivo. The cellular organisation, extracellular matrix and microvascular network mimic human heart tissue. These spheroids have been employed to inve ...[more]