Ontology highlight
ABSTRACT:
SUBMITTER: Cai CL
PROVIDER: S-EPMC5540369 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Cai Chen-Leng CL Martin Jody C JC Sun Yunfu Y Cui Li L Wang Lianchun L Ouyang Kunfu K Yang Lei L Bu Lei L Liang Xingqun X Zhang Xiaoxue X Stallcup William B WB Denton Christopher P CP McCulloch Andrew A Chen Ju J Evans Sylvia M SM
Nature 20080514 7200
Understanding the origins and roles of cardiac progenitor cells is important for elucidating the pathogenesis of congenital and acquired heart diseases. Moreover, manipulation of cardiac myocyte progenitors has potential for cell-based repair strategies for various myocardial disorders. Here we report the identification in mouse of a previously unknown cardiac myocyte lineage that derives from the proepicardial organ. These progenitor cells, which express the T-box transcription factor Tbx18, mi ...[more]