Ontology highlight
ABSTRACT:
SUBMITTER: Song Y
PROVIDER: S-EPMC5540791 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Song Yan Y Botvinnik Olga B OB Lovci Michael T MT Kakaradov Boyko B Liu Patrick P Xu Jia L JL Yeo Gene W GW
Molecular cell 20170629 1
Alternative splicing (AS) generates isoform diversity for cellular identity and homeostasis in multicellular life. Although AS variation has been observed among single cells, little is known about the biological or evolutionary significance of such variation. We developed Expedition, a computational framework consisting of outrigger, a de novo splice graph transversal algorithm to detect AS; anchor, a Bayesian approach to assign modalities; and bonvoyage, a visualization tool using non-negative ...[more]