Ontology highlight
ABSTRACT:
SUBMITTER: Sagner A
PROVIDER: S-EPMC5811045 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Sagner Andreas A Gaber Zachary B ZB Delile Julien J Kong Jennifer H JH Rousso David L DL Pearson Caroline A CA Weicksel Steven E SE Melchionda Manuela M Mousavy Gharavy S Neda SN Briscoe James J Novitch Bennett G BG
PLoS biology 20180201 2
During tissue development, multipotent progenitors differentiate into specific cell types in characteristic spatial and temporal patterns. We addressed the mechanism linking progenitor identity and differentiation rate in the neural tube, where motor neuron (MN) progenitors differentiate more rapidly than other progenitors. Using single cell transcriptomics, we defined the transcriptional changes associated with the transition of neural progenitors into MNs. Reconstruction of gene expression dyn ...[more]