Ontology highlight
ABSTRACT:
SUBMITTER: Luo C
PROVIDER: S-EPMC5541379 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Luo Cong C Sun Jin J Liu Dan D Sun Bingjun B Miao Lei L Musetti Sara S Li Jing J Han Xiaopeng X Du Yuqian Y Li Lin L Huang Leaf L He Zhonggui Z
Nano letters 20160808 9
Chemotherapeutic efficacy can be greatly improved by developing nanoparticulate drug delivery systems (nano-DDS) with high drug loading capacity and smart stimulus-triggered drug release in tumor cells. Herein, we report a novel redox dual-responsive prodrug-nanosystem self-assembled by hydrophobic small-molecule conjugates of paclitaxel (PTX) and oleic acid (OA). Thioether linked conjugates (PTX-S-OA) and dithioether inserted conjugates (PTX-2S-OA) are designed to respond to the redox-heterogen ...[more]