Ontology highlight
ABSTRACT:
SUBMITTER: Andrgie AT
PROVIDER: S-EPMC7023610 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Polymers 20191227 1
Polymeric prodrug-based delivery systems have been extensively studied to find a better solution for the limitations of a single drug and to improve the therapeutic and pharmacodynamics properties of chemotherapeutic agents, which can lead to efficient therapy. In this study, redox-responsive disulfide bond-containing amphiphilic heparin-chlorambucil conjugated polymeric prodrugs were designed and synthesized to enhance anti-tumor activities of chlorambucil. The conjugated prodrug could be self- ...[more]