Ontology highlight
ABSTRACT:
SUBMITTER: Lumb JH
PROVIDER: S-EPMC5551412 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Lumb Jennifer H JH Li Qin Q Popov Lauren M LM Ding Siyuan S Keith Marie T MT Merrill Bryan D BD Greenberg Harry B HB Li Jin Billy JB Carette Jan E JE
Cell reports 20170701 4
The innate immune system tightly regulates activation of interferon-stimulated genes (ISGs) to avoid inappropriate expression. Pathological ISG activation resulting from aberrant nucleic acid metabolism has been implicated in autoimmune disease; however, the mechanisms governing ISG suppression are unknown. Through a genome-wide genetic screen, we identified DEAD-box helicase 6 (DDX6) as a suppressor of ISGs. Genetic ablation of DDX6 induced global upregulation of ISGs and other immune genes. IS ...[more]