IRGD-functionalized PEGylated nanoparticles for enhanced colon tumor accumulation and targeted drug delivery.
Ontology highlight
ABSTRACT: Aim
To enhance the tumor accumulation and targeted drug delivery for colon cancer therapy, iRGD peptide was introduced to the surface of PEGylated camptothecin-loaded nanoparticles (NPs).Methods
Cellular uptake, targeting specificity, biodistribution and antitumor capacity were evaluated.Results
The functionalization of iRGD facilitated tumor accumulation and cellular uptake of NPs by Colon-26 cells. Furthermore, the resultant iRGD-PEG-NPs remarkably improved the therapeutic efficacy of camptothecin in vitro and in vivo by inducing a higher degree of tumor cell apoptosis compared with PEG-NPs.Conclusion
iRGD-PEG-NP is a desired drug delivery system to facilitate the drug accumulation in orthotopic colon tumor tissues and further drug internalization by colon cancer cells.
SUBMITTER: Ma L
PROVIDER: S-EPMC5551526 | biostudies-literature |
REPOSITORIES: biostudies-literature
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