Dataset Information

IRGD-functionalized PEGylated nanoparticles for enhanced colon tumor accumulation and targeted drug delivery.

ABSTRACT:

Aim

To enhance the tumor accumulation and targeted drug delivery for colon cancer therapy, iRGD peptide was introduced to the surface of PEGylated camptothecin-loaded nanoparticles (NPs).

Methods

Cellular uptake, targeting specificity, biodistribution and antitumor capacity were evaluated.

Results

The functionalization of iRGD facilitated tumor accumulation and cellular uptake of NPs by Colon-26 cells. Furthermore, the resultant iRGD-PEG-NPs remarkably improved the therapeutic efficacy of camptothecin in vitro and in vivo by inducing a higher degree of tumor cell apoptosis compared with PEG-NPs.

Conclusion

iRGD-PEG-NP is a desired drug delivery system to facilitate the drug accumulation in orthotopic colon tumor tissues and further drug internalization by colon cancer cells.

SUBMITTER: Ma L

PROVIDER: S-EPMC5551526 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Publications

iRGD-functionalized PEGylated nanoparticles for enhanced colon tumor accumulation and targeted drug delivery.

Ma Lijun L Chen Qiubing Q Ma Panpan P Han Moon Kwon MK Xu Zhigang Z Kang Yuejun Y Xiao Bo B Merlin Didier D

Nanomedicine (London, England) 20170726 16

<h4>Aim</h4>To enhance the tumor accumulation and targeted drug delivery for colon cancer therapy, iRGD peptide was introduced to the surface of PEGylated camptothecin-loaded nanoparticles (NPs).<h4>Methods</h4>Cellular uptake, targeting specificity, biodistribution and antitumor capacity were evaluated.<h4>Results</h4>The functionalization of iRGD facilitated tumor accumulation and cellular uptake of NPs by Colon-26 cells. Furthermore, the resultant iRGD-PEG-NPs remarkably improved the therapeu ...[more]

PMID: 28745123

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