Ontology highlight
ABSTRACT:
SUBMITTER: Soe ZC
PROVIDER: S-EPMC6920870 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Soe Zar Chi ZC Ou Wenquan W Gautam Milan M Poudel Kishwor K Kim Bo Kyun BK Pham Le Minh LM Phung Cao Dai CD Jeong Jee-Heon JH Jin Sung Giu SG Choi Han-Gon HG Ku Sae Kwang SK Yong Chul Soon CS Kim Jong Oh JO
Pharmaceutics 20191030 11
In this study, we investigated the active targeted delivery of a hydrophobic drug, paclitaxel (PTX), via receptor-mediated endocytosis by folate receptors expressed on cancer cells using a protein-based nanoparticle system. PTX was loaded on zein nanoparticles and conjugated with folate (PTX/Zein-FA) to estimate its chemotherapeutic efficacy in folate receptor-expressing KB cancer cells. PTX/Zein-FA nanoparticles were successfully developed, with a nanoparticle size of ~180 nm and narrow polydis ...[more]