Ontology highlight
ABSTRACT:
SUBMITTER: Nordholm J
PROVIDER: S-EPMC5551715 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Nordholm Johan J Petitou Jeanne J Östbye Henrik H da Silva Diogo V DV Dou Dan D Wang Hao H Daniels Robert R
The Journal of cell biology 20170710 8
A primary function of 5' regions in many secretory protein mRNAs is to encode an endoplasmic reticulum (ER) targeting sequence. In this study, we show how the regions coding for the ER-targeting sequences of the influenza glycoproteins NA and HA also function as translational regulatory elements that are controlled by the viral RNA-binding protein (RBP) NS1. The translational increase depends on the nucleotide composition and 5' positioning of the ER-targeting sequence coding regions and is faci ...[more]