Presence of both A1 and A2a adenosine receptors in human cells and their interaction.
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ABSTRACT:
SUBMITTER: Ahmed AH
PROVIDER: S-EPMC5553076 | biostudies-literature | 1995 Mar
REPOSITORIES: biostudies-literature
Publications
Presence of both A1 and A2a adenosine receptors in human cells and their interaction.
Ahmed A H AH Jacobson K A KA Kim J J Heppel L A LA
Biochemical and biophysical research communications 19950301 2
We have obtained pharmacological evidence for the expression of both A1- (inhibitory) and A2a- (stimulatory) adenosine receptors in cultured human foreskin fibroblasts and lung fibroblasts. The A1 receptors were sufficiently abundant in foreskin fibroblasts so that binding studies with a radioactively labeled specific ligand confirmed their existence. Both receptors were activated during the stimulation of cAMP accumulation and DNA synthesis by adenosine. ...[more]
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