Adenosine A1 and A2A Receptors in the Brain: Current Research and Their Role in Neurodegeneration.
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ABSTRACT:
SUBMITTER: Stockwell J
PROVIDER: S-EPMC6154612 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
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Adenosine A1 and A2A Receptors in the Brain: Current Research and Their Role in Neurodegeneration.
Stockwell Jocelyn J Jakova Elisabet E Cayabyab Francisco S FS
Molecules (Basel, Switzerland) 20170423 4
The inhibitory adenosine A1 receptor (A1R) and excitatory A2A receptor (A2AR) are predominantly expressed in the brain. Whereas the A2AR has been implicated in normal aging and enhancing neurotoxicity in multiple neurodegenerative diseases, the inhibitory A1R has traditionally been ascribed to have a neuroprotective function in various brain insults. This review provides a summary of the emerging role of prolonged A1R signaling and its potential cross-talk with A2AR in the cellular basis for inc ...[more]
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