Ontology highlight
ABSTRACT:
SUBMITTER: Berry BJ
PROVIDER: S-EPMC7756364 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Berry Brandon J BJ Baldzizhar Aksana A Nieves Tyrone O TO Wojtovich Andrew P AP
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20201015 12
Organisms adapt to their environment through coordinated changes in mitochondrial function and metabolism. The mitochondrial protonmotive force (PMF) is an electrochemical gradient that powers ATP synthesis and adjusts metabolism to energetic demands via cellular signaling. It is unknown how or where transient PMF changes are sensed and signaled due to the lack of precise spatiotemporal control in vivo. We addressed this by expressing a light-activated proton pump in mitochondria to spatiotempor ...[more]