A Novel Aldosterone Antagonist Limits Renal Injury in 5/6 Nephrectomy.
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ABSTRACT:
SUBMITTER: Fujihara CK
PROVIDER: S-EPMC5554220 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Publications
A Novel Aldosterone Antagonist Limits Renal Injury in 5/6 Nephrectomy.
Fujihara Clarice K CK Kowala M C MC Breyer M D MD Sena Claudia R CR Rodrigues Mariliza V MV Arias Simone C A SCA Fanelli Camilla C Malheiros Denise M DM Jadhav P K PK Montrose-Rafizadeh Chahrzad C Krieger Jose E JE Zatz Roberto R
Scientific reports 20170811 1
Aldosterone antagonists slow the progression of chronic kidney disease (CKD), but their use is limited by hyperkalemia, especially when associated with RAS inhibitors. We examined the renoprotective effects of Ly, a novel non-steroidal mineralocorticoid receptor (MR) blocker, through two experimental protocols: In Protocol 1, male Munich-Wistar rats underwent 5/6 renal ablation (Nx), being divided into: Nx+V, receiving vehicle, Nx+Eple, given eplerenone, 150 mg/kg/day, and Nx+Ly, given Ly, 20 mg ...[more]
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