Ontology highlight
ABSTRACT:
SUBMITTER: Onfroy L
PROVIDER: S-EPMC5554226 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Scientific reports 20170811 1
Biased agonism at G protein coupled receptors emerges as an opportunity for development of drugs with enhanced benefit/risk balance making biased ligand identification a priority. However, ligand biased signature, classically inferred from ligand activity across multiple pathways, displays high variability in recombinant systems. Functional assays usually necessity receptor/effector overexpression that should be controlled among assays to allow comparison but this calibration currently fails. He ...[more]