Ontology highlight
ABSTRACT:
SUBMITTER: Reyes-Alcaraz A
PROVIDER: S-EPMC6123711 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Reyes-Alcaraz Arfaxad A Lee Yoo-Na YN Yun Seongsik S Hwang Jong-Ik JI Seong Jae Young JY
Communications biology 20180903
Discovery of biased ligands and receptor mutants allows characterization of G-protein- and β-arrestin-mediated signaling mechanisms of G-protein-coupled receptors (GPCRs). However, the structural mechanisms underlying biased agonism remain unclear for many GPCRs. We show that while Galanin induces the activation of the galanin receptor 2 (Galr2) that leads to a robust stimulation toward Gαq-protein and β-arrestin1/2, an alternative ligand Spexin and its analog have biased agonism toward G-protei ...[more]