Metalloproteinases as mediators of inflammation and the eyes: molecular genetic underpinnings governing ocular pathophysiology.
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ABSTRACT:
SUBMITTER: Singh M
PROVIDER: S-EPMC5554853 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Metalloproteinases as mediators of inflammation and the eyes: molecular genetic underpinnings governing ocular pathophysiology.
Singh Mahavir M Tyagi Suresh C SC
International journal of ophthalmology 20170818 8
There are many vision threatening diseases of the eye affecting millions of people worldwide. In this article, we are summarizing potential role of various matrix metalloproteinases (MMPs); the Zn (2+)-dependent endoproteases in eye health along with pathogenesis of prominent ocular diseases such as macular degeneration, diabetic retinopathy, and glaucoma <i>via</i> understanding MMPs regulation in affected patients, interactions of MMPs with their substrate molecules, and key regulatory functio ...[more]
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