Ontology highlight
ABSTRACT:
SUBMITTER: Bhatia V
PROVIDER: S-EPMC7170719 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Trends in molecular medicine 20190725 11
Inter- and intra-patient molecular heterogeneity of primary and metastatic prostate cancer (PCa) confers variable clinical outcome and poses a formidable challenge in disease management. High-throughput integrative genomics and functional approaches have untangled the complexity involved in this disease and revealed a spectrum of diverse aberrations prevalent in various molecular subtypes, including ETS fusion negative. Emerging evidence indicates that SPINK1 upregulation, mutations in epigeneti ...[more]