Ontology highlight
ABSTRACT:
SUBMITTER: Mazzulli JR
PROVIDER: S-EPMC5555314 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Mazzulli Joseph R JR Burbulla Lena F LF Krainc Dimitri D Ischiropoulos Harry H
Analytical chemistry 20160203 4
Aging and oxidative stress are two prominent pathological mechanisms for Parkinson's disease (PD) that are strongly associated with the degeneration of dopamine (DA) neurons in the midbrain. DA and other catechols readily oxidize into highly reactive o-quinone species that are precursors of neuromelanin (NM) pigment and under pathological conditions can modify and damage macromolecules. The role of DA oxidation in PD pathogenesis remains unclear in part due to the lack of appropriate disease mod ...[more]