Ontology highlight
ABSTRACT:
SUBMITTER: Webb LM
PROVIDER: S-EPMC5556270 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Webb Lauren M LM Lundie Rachel J RJ Borger Jessica G JG Brown Sheila L SL Connor Lisa M LM Cartwright Adam Nr AN Dougall Annette M AM Wilbers Ruud Hp RH Cook Peter C PC Jackson-Jones Lucy H LH Phythian-Adams Alexander T AT Johansson Cecilia C Davis Daniel M DM Dewals Benjamin G BG Ronchese Franca F MacDonald Andrew S AS
The EMBO journal 20170717 16
Type 2 inflammation is a defining feature of infection with parasitic worms (helminths), as well as being responsible for widespread suffering in allergies. However, the precise mechanisms involved in T helper (Th) 2 polarization by dendritic cells (DCs) are currently unclear. We have identified a previously unrecognized role for type I IFN (IFN-I) in enabling this process. An IFN-I signature was evident in DCs responding to the helminth <i>Schistosoma mansoni</i> or the allergen house dust mite ...[more]