Ontology highlight
ABSTRACT:
SUBMITTER: Vavricka CJ
PROVIDER: S-EPMC5557986 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Vavricka Christopher J CJ Muto Chiaki C Hasunuma Tomohisa T Kimura Yoshinobu Y Araki Michihiro M Wu Yan Y Gao George F GF Ohrui Hiroshi H Izumi Minoru M Kiyota Hiromasa H
Scientific reports 20170815 1
The design, synthesis and application of N-acetylneuraminic acid-derived compounds bearing anomeric sulfo functional groups are described. These novel compounds, which we refer to as sulfo-sialic acid analogues, include 2-decarboxy-2-deoxy-2-sulfo-N-acetylneuraminic acid and its 4-deoxy-3,4-dehydrogenated pseudoglycal. While 2-decarboxy-2-deoxy-2-sulfo-N-acetylneuraminic acid contains no further modifications of the 2-deoxy-pyranose ring, it is still a more potent inhibitor of avian-origin H5N1 ...[more]