Ontology highlight
ABSTRACT:
SUBMITTER: Huta BP
PROVIDER: S-EPMC5558615 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Huta Brian P BP Mehlenbacher Matthew R MR Nie Yan Y Lai Xuelei X Zubieta Chloe C Bou-Abdallah Fadi F Doyle Robert P RP
ChemMedChem 20151130 3
Chloroquine (CQ) has been widely used in the treatment of malaria since the 1950s, though toxicity and resistance is increasingly limiting its use in the clinic. More recently, CQ is also becoming recognized as an important therapeutic compound for the treatment of autoimmune disorders and has shown activity as an anticancer agent. However, the full extent of CQ pharmacology in humans is still unclear. Herein, we demonstrate that the lysosomal protein saposin B (sapB), critical for select lipid ...[more]