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Fenretinide binding to the lysosomal protein saposin D alters ceramide solubilization and hydrolysis.


ABSTRACT: Fenretinide is a synthetic retinoid pharmaceutical linked to ceramide build-up in vivo. Saposin D is an intralysosomal protein necessary for ceramide binding/degradation. We show, via electronic absorption spectroscopy, fluorescence spectroscopy, and ceramide hydrolysis assays, that fenretinide is bound by saposin D {K a = (1.45 ± 0.49) × 105 M-1}, and affects ceramide solubilization/degradation.

SUBMITTER: Milliken BT 

PROVIDER: S-EPMC7513591 | biostudies-literature |

REPOSITORIES: biostudies-literature

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