Ontology highlight
ABSTRACT:
SUBMITTER: Skardal A
PROVIDER: S-EPMC5562747 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Skardal Aleksander A Murphy Sean V SV Devarasetty Mahesh M Mead Ivy I Kang Hyun-Wook HW Seol Young-Joon YJ Shrike Zhang Yu Y Shin Su-Ryon SR Zhao Liang L Aleman Julio J Hall Adam R AR Shupe Thomas D TD Kleensang Andre A Dokmeci Mehmet R MR Jin Lee Sang S Jackson John D JD Yoo James J JJ Hartung Thomas T Khademhosseini Ali A Soker Shay S Bishop Colin E CE Atala Anthony A
Scientific reports 20170818 1
Many drugs have progressed through preclinical and clinical trials and have been available - for years in some cases - before being recalled by the FDA for unanticipated toxicity in humans. One reason for such poor translation from drug candidate to successful use is a lack of model systems that accurately recapitulate normal tissue function of human organs and their response to drug compounds. Moreover, tissues in the body do not exist in isolation, but reside in a highly integrated and dynamic ...[more]