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Zika virus evolution and spread in the Americas.


ABSTRACT: Although the recent Zika virus (ZIKV) epidemic in the Americas and its link to birth defects have attracted a great deal of attention, much remains unknown about ZIKV disease epidemiology and ZIKV evolution, in part owing to a lack of genomic data. Here we address this gap in knowledge by using multiple sequencing approaches to generate 110 ZIKV genomes from clinical and mosquito samples from 10 countries and territories, greatly expanding the observed viral genetic diversity from this outbreak. We analysed the timing and patterns of introductions into distinct geographic regions; our phylogenetic evidence suggests rapid expansion of the outbreak in Brazil and multiple introductions of outbreak strains into Puerto Rico, Honduras, Colombia, other Caribbean islands, and the continental United States. We find that ZIKV circulated undetected in multiple regions for many months before the first locally transmitted cases were confirmed, highlighting the importance of surveillance of viral infections. We identify mutations with possible functional implications for ZIKV biology and pathogenesis, as well as those that might be relevant to the effectiveness of diagnostic tests.

SUBMITTER: Metsky HC 

PROVIDER: S-EPMC5563848 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Zika virus evolution and spread in the Americas.

Metsky Hayden C HC   Matranga Christian B CB   Wohl Shirlee S   Schaffner Stephen F SF   Freije Catherine A CA   Winnicki Sarah M SM   West Kendra K   Qu James J   Baniecki Mary Lynn ML   Gladden-Young Adrianne A   Lin Aaron E AE   Tomkins-Tinch Christopher H CH   Ye Simon H SH   Park Daniel J DJ   Luo Cynthia Y CY   Barnes Kayla G KG   Shah Rickey R RR   Chak Bridget B   Barbosa-Lima Giselle G   Delatorre Edson E   Vieira Yasmine R YR   Paul Lauren M LM   Tan Amanda L AL   Barcellona Carolyn M CM   Porcelli Mario C MC   Vasquez Chalmers C   Cannons Andrew C AC   Cone Marshall R MR   Hogan Kelly N KN   Kopp Edgar W EW   Anzinger Joshua J JJ   Garcia Kimberly F KF   Parham Leda A LA   Ramírez Rosa M Gélvez RMG   Montoya Maria C Miranda MCM   Rojas Diana P DP   Brown Catherine M CM   Hennigan Scott S   Sabina Brandon B   Scotland Sarah S   Gangavarapu Karthik K   Grubaugh Nathan D ND   Oliveira Glenn G   Robles-Sikisaka Refugio R   Rambaut Andrew A   Gehrke Lee L   Smole Sandra S   Halloran M Elizabeth ME   Villar Luis L   Mattar Salim S   Lorenzana Ivette I   Cerbino-Neto Jose J   Valim Clarissa C   Degrave Wim W   Bozza Patricia T PT   Gnirke Andreas A   Andersen Kristian G KG   Isern Sharon S   Michael Scott F SF   Bozza Fernando A FA   Souza Thiago M L TML   Bosch Irene I   Yozwiak Nathan L NL   MacInnis Bronwyn L BL   Sabeti Pardis C PC  

Nature 20170524 7658


Although the recent Zika virus (ZIKV) epidemic in the Americas and its link to birth defects have attracted a great deal of attention, much remains unknown about ZIKV disease epidemiology and ZIKV evolution, in part owing to a lack of genomic data. Here we address this gap in knowledge by using multiple sequencing approaches to generate 110 ZIKV genomes from clinical and mosquito samples from 10 countries and territories, greatly expanding the observed viral genetic diversity from this outbreak.  ...[more]

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