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ABSTRACT: Objective
To compare the frequency and risk factors of toxicity-related treatment discontinuations between raltegravir and dolutegravir.Design
Prospective cohort study.Methods
All antiretroviral therapy (ART)-naïve and ART-experienced HIV-infected individuals from the Swiss HIV Cohort Study who initiated raltegravir or dolutegravir between 2006 and 2015 were investigated concerning treatment modification within the first year.Results
Of 4041 patients initiating ART containing raltegravir (n?=?2091) or dolutegravir (n?=?1950), 568 patients discontinued ART during the first year, corresponding to a rate of 15.5 [95% confidence interval (CI) 14.5-16.9] discontinuations per 100 patient-years. Only 10 patients on raltegravir (0.5%) and two patients on dolutegravir (0.1%) demonstrated virologic failure. The main reason for ART discontinuation was convenience expressed as patient's wish, physician's decision, or treatment simplification (n?=?302). Toxicity occurred in 4.3% of patients treated with raltegravir and 3.6% with dolutegravir, respectively. In multivariable analysis, the only independent risk factor for discontinuing ART because of toxicity was female sex (hazard ratio 1.98, 95% CI 1.45-2.71, P?ConclusionIn this, large cohort raltegravir and dolutegravir-containing regimen demonstrated a high virologic efficacy. Drug toxicity was infrequent and discontinuation because of neuropsychiatric events within the first year of treatment was only marginal higher with dolutegravir compared with raltegravir. However, monitoring of neurotoxic side-effects of dolutegravir is important.
SUBMITTER: Elzi L
PROVIDER: S-EPMC5566167 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Elzi Luigia L Erb Stefan S Furrer Hansjakob H Cavassini Matthias M Calmy Alexandra A Vernazza Pietro P Günthard Huldrych H Bernasconi Enos E Battegay Manuel M
AIDS (London, England) 20170801 13
<h4>Objective</h4>To compare the frequency and risk factors of toxicity-related treatment discontinuations between raltegravir and dolutegravir.<h4>Design</h4>Prospective cohort study.<h4>Methods</h4>All antiretroviral therapy (ART)-naïve and ART-experienced HIV-infected individuals from the Swiss HIV Cohort Study who initiated raltegravir or dolutegravir between 2006 and 2015 were investigated concerning treatment modification within the first year.<h4>Results</h4>Of 4041 patients initiating AR ...[more]