Proteomics

Dataset Information

0

Platelet proteomics profiling in transfusion adverse events


ABSTRACT: Blood platelets destined for transfusion release panoply of molecules during preparation and storage. The leukoreduction process made the transfusion safer but did not completely abolish the adverse events. The rationale is to study the proteome profile of platelet components SDA-PC (platelet pellets) involved in transfusion adverse events.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Platelet, Blood Cell

SUBMITTER: Stephane Claverol  

LAB HEAD: Marc Bonneu

PROVIDER: PXD008886 | Pride | 2019-02-13

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
sl170213-files.xlsx Xlsx
sl170213_10_01.msf Msf
sl170213_10_01.raw Raw
sl170213_10_02.msf Msf
sl170213_10_02.raw Raw
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Publications

Dysregulated pathways and differentially expressed proteins associated with adverse transfusion reactions in different types of platelet components.

Aloui Chaker C   Barlier Céline C   Awounou Danielle D   Thiam Saliou S   Fagan Jocelyne J   Claverol Stéphane S   Tavernier Emmanuelle E   Mounier Christiane C   Hamzeh-Cognasse Hind H   Cognasse Fabrice F   Garraud Olivier O   Laradi Sandrine S  

Journal of proteomics 20200220


Platelet components (PCs) are occasionally associated with adverse transfusion reactions (ATRs). ATRs can occur regardless of the type of PC being transfused, whether it is a single-donor apheresis PC (SDA-PC) or a pooled PC (PPCs). The purpose of this study was to investigate the proteins and dysregulated pathways in both of the main types of PCs. The proteomic profiles of platelet pellets from SDA-PCs and PPCs involved in ATRs were analysed using the label-free LC-MS/MS method. Differentially  ...[more]

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