Hepatic overproduction of 13-HODE due to ALOX15 upregulation contributes to alcohol-induced liver injury in mice.
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ABSTRACT:
SUBMITTER: Zhang W
PROVIDER: S-EPMC5567196 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
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Hepatic overproduction of 13-HODE due to ALOX15 upregulation contributes to alcohol-induced liver injury in mice.
Zhang Wenliang W Zhong Wei W Sun Qian Q Sun Xinguo X Zhou Zhanxiang Z
Scientific reports 20170821 1
Chronic alcohol feeding causes lipid accumulation and apoptosis in the liver. This study investigated the role of bioactive lipid metabolites in alcohol-induced liver damage and tested the potential of targeting arachidonate 15-lipoxygenase (ALOX15) in treating alcoholic liver disease (ALD). Results showed that chronic alcohol exposure induced hepatocyte apoptosis in association with increased hepatic 13-HODE. Exposure of 13-HODE to Hepa-1c1c7 cells induced oxidative stress, ER stress and apopto ...[more]
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