Ontology highlight
ABSTRACT:
SUBMITTER: Luther J
PROVIDER: S-EPMC7261084 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Luther Jay J Khan Sanjoy S Gala Manish K MK Kedrin Dmitriy D Sridharan Gautham G Goodman Russell P RP Garber John J JJ Masia Ricard R Diagacomo Erik E Adams Daniel D King Kevin R KR Piaker Samuel S Reinecker Hans-Christian HC Yarmush Martin L ML Argemi Josepmaria J Bataller Ramon R Dienstag Jules L JL Chung Raymond T RT Patel Suraj J SJ
Proceedings of the National Academy of Sciences of the United States of America 20200511 21
Alcohol-related liver disease (ALD) accounts for the majority of cirrhosis and liver-related deaths worldwide. Activation of IFN-regulatory factor (IRF3) initiates alcohol-induced hepatocyte apoptosis, which fuels a robust secondary inflammatory response that drives ALD. The dominant molecular mechanism by which alcohol activates IRF3 and the pathways that amplify inflammatory signals in ALD remains unknown. Here we show that cytoplasmic sensor cyclic guanosine monophosphate-adenosine monophosph ...[more]