Ontology highlight
ABSTRACT:
SUBMITTER: Zuo Y
PROVIDER: S-EPMC5567806 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Zuo Yuhong Y Steitz Thomas A TA
Molecular cell 20150409 3
During transcription initiation, RNA polymerase binds to promoter DNA to form an initiation complex containing a DNA bubble and enters into abortive cycles of RNA synthesis before escaping the promoter to transit into the elongation phase for processive RNA synthesis. Here we present the crystal structures of E. coli transcription initiation complexes containing a complete transcription bubble and de novo synthesized RNA oligonucleotides at about 6-Å resolution. The structures show how RNA polym ...[more]