Ontology highlight
ABSTRACT:
SUBMITTER: Schumann B
PROVIDER: S-EPMC5573155 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Schumann Benjamin B Hahm Heung Sik HS Parameswarappa Sharavathi G SG Reppe Katrin K Wahlbrink Annette A Govindan Subramanian S Kaplonek Paulina P Pirofski Liise-Anne LA Witzenrath Martin M Anish Chakkumkal C Pereira Claney L CL Seeberger Peter H PH
Science translational medicine 20170301 380
Glycoconjugate vaccines based on capsular polysaccharides (CPSs) of pathogenic bacteria such as <i>Streptococcus pneumoniae</i> successfully protect from disease but suffer from incomplete coverage, are troublesome to manufacture from isolated CPSs, and lack efficacy against certain serotypes. Defined, synthetic oligosaccharides are an attractive alternative to isolated CPSs but require the identification of immunogenic and protective oligosaccharide antigens. We describe a medicinal chemistry s ...[more]