Ontology highlight
ABSTRACT:
SUBMITTER: Schumann B
PROVIDER: S-EPMC5879475 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Schumann Benjamin B Reppe Katrin K Kaplonek Paulina P Wahlbrink Annette A Anish Chakkumkal C Witzenrath Martin M Pereira Claney L CL Seeberger Peter H PH
ACS central science 20180314 3
Infections with <i>Streptococcus pneumoniae</i> are a major health burden. Glycoconjugate vaccines based on capsular polysaccharides (CPSs) successfully protect from infection, but not all pneumococcal serotypes are covered with equal potency. Marketed glycoconjugate vaccines induce low levels of functional antibodies against the highly invasive serotype 1 (ST1), presumably due to the obscuring of protective epitopes during chemical activation and conjugation to carrier proteins. Synthetic oligo ...[more]