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Cyclophosphamide for Prevention of Graft-Versus-Host Disease After Allogeneic Peripheral Blood Stem Cell Transplantation in Patients With Hematological Malignancies


ABSTRACT: This phase II trial studies how well cyclophosphamide works in preventing chronic graft-versus-host disease after allogeneic peripheral blood stem cell transplant in patients with hematological malignancies. Giving chemotherapy and total-body irradiation before transplantation helps stop the growth of cancer cells and prevents the patient’s immune system from rejecting the donor’s stem cells. Healthy stem cells from a donor that are infused into the patient help the patient’s bone marrow make blood cells; red blood cells, white blood cells, and platelets. Sometimes, however, the transplanted donor cells can cause an immune response against the body’s normal cells, which is called graft-versus-host disease (GVHD). Giving cyclophosphamide after transplant may prevent this from happening or may make chronic GVHD less severe.

DISEASE(S): Recurrent Childhood Small Noncleaved Cell Lymphoma,Blastic Phase Chronic Myelogenous Leukemia,Lymphoma, Large-cell, Immunoblastic,Lymphoproliferative Disorders,Recurrent Childhood Anaplastic Large Cell Lymphoma,Childhood Acute Megakaryocytic Leukemia (m7),Childhood Burkitt Lymphoma,Recurrent Grade 1 Follicular Lymphoma,Childhood Immunoblastic Large Cell Lymphoma,Mycosis Fungoides,Previously Treated Myelodysplastic Syndromes,Recurrent Adult Burkitt Lymphoma,Leukemia, T-cell,Lymphomatoid Granulomatosis,De Novo Myelodysplastic Syndromes,Lymphoma, T-cell, Peripheral,Preleukemia,Lymphoma, B-cell, Marginal Zone,Leukemia, Myelogenous, Chronic, Bcr-abl Positive,Adult Erythroleukemia (m6a),Nodal Marginal Zone B-cell Lymphoma,Childhood Diffuse Large Cell Lymphoma,Recurrent Small Lymphocytic Lymphoma,Lymphoma, T-cell, Cutaneous,Lymphoma, Follicular,Waldenstrom Macroglobulinemia,Leukemia, Myeloid, Accelerated Phase,Recurrent Mantle Cell Lymphoma,Relapsing Chronic Myelogenous Leukemia,Chronic Phase Chronic Myelogenous Leukemia,Recurrent Childhood Acute Lymphoblastic Leukemia,Childhood Chronic Myelogenous Leukemia,Leukemia,Hodgkin Disease,Recurrent Adult Hodgkin Lymphoma,Mycoses,Recurrent Adult Lymphoblastic Lymphoma,Recurrent Childhood Large Cell Lymphoma,Leukemia, Myeloid, Acute,Leukemia, Myelomonocytic, Chronic,Testicular Lymphoma,Lymphoma, T-cell,Blast Crisis,Philadelphia Chromosome,Myelodysplastic Syndromes,Leukemia, Myelomonocytic, Juvenile,Recurrent Adult Acute Myeloid Leukemia,Leukemia, Myeloid,Immunoblastic Lymphadenopathy,Stage Iii Multiple Myeloma,Recurrent Adult Diffuse Mixed Cell Lymphoma,Philadelphia Chromosome Negative Chronic Myelogenous Leukemia,Recurrent Adult T-cell Leukemia/lymphoma,Childhood Acute Lymphoblastic Leukemia In Remission,Lymphoma, Non-hodgkin,Recurrent Adult Diffuse Large Cell Lymphoma,Lymphoma, B-cell,Graft Vs Host Disease,Extranodal Marginal Zone B-cell Lymphoma Of Mucosa-associated Lymphoid Tissue,Lymphoma, Large B-cell, Diffuse,Adult Acute Megakaryoblastic Leukemia (m7),Leukemia, Myeloid, Chronic-phase,Small Intestine Lymphoma,Childhood Acute Myeloid Leukemia In Remission,Sezary Syndrome,Neoplasm Metastasis,Adult Nasal Type Extranodal Nk/t-cell Lymphoma,Secondary Acute Myeloid Leukemia,Splenic Marginal Zone Lymphoma,Lymphoma, Mantle-cell,Leukemia-lymphoma, Adult T-cell,Adult Acute Myeloid Leukemia In Remission,Recurrent Adult Immunoblastic Large Cell Lymphoma,Recurrent Childhood Acute Myeloid Leukemia,Multiple Myeloma,Recurrent Childhood Lymphoblastic Lymphoma,Leukemia, Megakaryoblastic, Acute,Lymphoma, Extranodal Nk-t-cell,Plasmablastic Lymphoma,Adult Pure Erythroid Leukemia (m6b),Burkitt Lymphoma,Chronic Myelomonocytic Leukemia,Recurrent Adult Diffuse Small Cleaved Cell Lymphoma,Post-transplant Lymphoproliferative Disorder,Recurrent Marginal Zone Lymphoma,Recurrent Adult Grade Iii Lymphomatoid Granulomatosis,Leukemia, Lymphocytic, Chronic, B-cell,Intraocular Lymphoma,Recurrent Adult Acute Lymphoblastic Leukemia,Recurrent Grade 3 Follicular Lymphoma,Childhood Acute Erythroleukemia (m6),Accelerated Phase Chronic Myelogenous Leukemia,Adult Acute Lymphoblastic Leukemia In Remission,Waldenström Macroglobulinemia,Recurrent Childhood Grade Iii Lymphomatoid Granulomatosis,Noncutaneous Extranodal Lymphoma,Angioimmunoblastic T-cell Lymphoma,Lymphoma, Large-cell, Anaplastic,Hepatosplenic T-cell Lymphoma,Leukemia, Lymphoid,Secondary Myelodysplastic Syndromes,Precursor Cell Lymphoblastic Leukemia-lymphoma,Recurrent Cutaneous T-cell Non-hodgkin Lymphoma,Lymphoma,Childhood Nasal Type Extranodal Nk/t-cell Lymphoma,Recurrent Mycosis Fungoides/sezary Syndrome,Childhood Myelodysplastic Syndromes,Anaplastic Large Cell Lymphoma,Recurrent Grade 2 Follicular Lymphoma,Peripheral T-cell Lymphoma,Leukemia, Erythroblastic, Acute,Recurrent/refractory Childhood Hodgkin Lymphoma,Cutaneous B-cell Non-hodgkin Lymphoma

PROVIDER: 2112331 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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