Hypomorphic conditional deletion of E11/Podoplanin reveals a role in osteocyte dendrite elongation.
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ABSTRACT:
SUBMITTER: Staines KA
PROVIDER: S-EPMC5575468 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
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Hypomorphic conditional deletion of E11/Podoplanin reveals a role in osteocyte dendrite elongation.
Staines Katherine A KA Javaheri Behzad B Hohenstein Peter P Fleming Robert R Ikpegbu Ekele E Unger Erin E Hopkinson Mark M Buttle David J DJ Pitsillides Andrew A AA Farquharson Colin C
Journal of cellular physiology 20170614 11
The transmembrane glycoprotein E11/Podoplanin (Pdpn) has been implicated in the initial stages of osteocyte differentiation. However, its precise function and regulatory mechanisms are still unknown. Due to the known embryonic lethality induced by global Pdpn deletion, we have herein explored the effect of bone-specific Pdpn knockdown on osteocyte form and function in the post-natal mouse. Extensive skeletal phenotyping of male and female 6-week-old Oc-cre;Pdpn<sup>flox/flox</sup> (cKO) mice and ...[more]
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