Ontology highlight
ABSTRACT:
SUBMITTER: Guimaraes-Young A
PROVIDER: S-EPMC5521196 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Developmental biology 20160419 2
The importance of canonical Wnt signaling to murine uterine development is well established. Mouse models in which uterine-specific Wnt ligands, β-catenin, or Lef1 are disrupted result in failure of postnatal endometrial gland development. Sox17 is a transcription factor characterized in numerous tissues as an antagonist of Wnt signaling. Thus, we hypothesized that conditional ablation of Sox17 would lead to hyperproliferation of endometrial glands in mice. Contrary to our prediction, disruption ...[more]