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Copper-catalyzed oxidative C(sp³)-H/C(sp²)-H cross-coupling en route to carbocyclic rings.

ABSTRACT: Copper-catalyzed selective coupling of C(sp³)-H bonds with C(sp²)-H bonds has been developed. An aniline module was used as a directing group to generate an aminyl radical, which selectively cleaves the secondary and tertiary C(sp³)-H bonds via a 1,5-HAT process to forge six-membered carbocyclic rings.

SUBMITTER: Wang R

PROVIDER: S-EPMC5577718 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Copper-catalyzed oxidative C(sp3)-H/C(sp2)-H cross-coupling en route to carbocyclic rings.

Wang Rui R Li Yan Y Li Yan Y Jin Ruo-Xing RX Wang Xi-Sheng XS

Chemical science 20170315 5

Copper-catalyzed selective coupling of C(sp3)-H bonds with C(sp2)-H bonds has been developed. An aniline module was used as a directing group to generate an aminyl radical, which selectively cleaves the secondary and tertiary C(sp3)-H bonds via a 1,5-HAT process to forge six-membered carbocyclic rings. ...[more]

PMID: 28966775

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