Ontology highlight
ABSTRACT:
SUBMITTER: Bao X
PROVIDER: S-EPMC6377619 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Nature communications 20190215 1
The Hofmann-Löffler-Freytag (HLF) reaction is a prototypical example of radical-based remote functionalization of unactivated C(sp<sup>3</sup>)-H bond. While 1,5-hydrogen atom transfer (1,5-HAT) of the amidyl radical is thermodynamically favorable and is well-established, the method for the subsequent functionalization of the translocated carbon radical is still limited. We report herein two catalytic remote C(sp<sup>3</sup>)-H functionalization protocols. Cu(MeCN)<sub>4</sub>PF<sub>6</sub>-cata ...[more]