Ontology highlight
ABSTRACT:
SUBMITTER: Entzminger KC
PROVIDER: S-EPMC5579192 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Entzminger Kevin C KC Hyun Jeong-Min JM Pantazes Robert J RJ Patterson-Orazem Athena C AC Qerqez Ahlam N AN Frye Zach P ZP Hughes Randall A RA Ellington Andrew D AD Lieberman Raquel L RL Maranas Costas D CD Maynard Jennifer A JA
Scientific reports 20170831 1
Computational antibody engineering efforts to date have focused on improving binding affinities or biophysical characteristics. De novo design of antibodies binding specific epitopes could greatly accelerate discovery of therapeutics as compared to conventional immunization or synthetic library selection strategies. Here, we employed de novo complementarity determining region (CDR) design to engineer targeted antibody-antigen interactions using previously described in silico methods. CDRs predic ...[more]