Ontology highlight
ABSTRACT:
SUBMITTER: Saadaoui M
PROVIDER: S-EPMC5579374 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Saadaoui Mehdi M Konno Daijiro D Loulier Karine K Goiame Rosette R Jadhav Vaibhav V Mapelli Marina M Matsuzaki Fumio F Morin Xavier X
EMBO reports 20170706 9
In many cell types, mitotic spindle orientation relies on the canonical "LGN complex" composed of Pins/LGN, Mud/NuMA, and Gα<sub>i</sub> subunits. Membrane localization of this complex recruits motor force generators that pull on astral microtubules to orient the spindle. <i>Drosophila</i> Pins shares highly conserved functional domains with its two vertebrate homologs LGN and AGS3. Whereas the role of Pins and LGN in oriented divisions is extensively documented, involvement of AGS3 remains cont ...[more]