Ontology highlight
ABSTRACT:
SUBMITTER: Palomera-Sanchez Z
PROVIDER: S-EPMC5583029 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Palomera-Sanchez Zoraya Z Watson Gregory W GW Wong Carmen P CP Beaver Laura M LM Williams David E DE Dashwood Roderick H RH Ho Emily E
The Journal of nutritional biochemistry 20170525
Androgen receptor (AR) is a transcription factor involved in normal prostate physiology and prostate cancer (PCa) development. 3,3'-Diindolylmethane (DIM) is a promising phytochemical agent against PCa that affects AR activity and epigenetic regulators in PCa cells. However, whether DIM suppresses PCa via epigenetic regulation of AR target genes is unknown. We assessed epigenetic regulation of AR target genes in LNCaP PCa cells and showed that DIM treatment led to epigenetic suppression of AR ta ...[more]