Ontology highlight
ABSTRACT:
SUBMITTER: Pellicci DG
PROVIDER: S-EPMC5584936 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Pellicci Daniel G DG Clarke Andrew J AJ Patel Onisha O Mallevaey Thierry T Beddoe Travis T Le Nours Jérôme J Uldrich Adam P AP McCluskey James J Besra Gurdyal S GS Porcelli Steven A SA Gapin Laurent L Godfrey Dale I DI Rossjohn Jamie J
Nature immunology 20110731 9
The most potent foreign antigens for natural killer T cells (NKT cells) are α-linked glycolipids, whereas NKT cell self-reactivity involves weaker recognition of structurally distinct β-linked glycolipid antigens. Here we provide the mechanism for the autoreactivity of T cell antigen receptors (TCRs) on NKT cells to the mono- and tri-glycosylated β-linked agonists β-galactosylceramide (β-GalCer) and isoglobotrihexosylceramide (iGb3), respectively. In binding these disparate antigens, the NKT cel ...[more]