Ontology highlight
ABSTRACT:
SUBMITTER: Sachen KL
PROVIDER: S-EPMC3501716 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Sachen Kacey L KL Strohman Michael J MJ Singletary Jonathan J Alizadeh Ash A AA Kattah Nicole H NH Lossos Chen C Mellins Elizabeth D ED Levy Shoshana S Levy Ronald R
Blood 20120928 20
Follicular lymphoma is a monoclonal B-cell malignancy with each patient's tumor expressing a unique cell surface immunoglobulin (Ig), or B-cell receptor (BCR), that can potentially recognize antigens and/or transduce signals into the tumor cell. Here we evaluated the reactivity of tumor derived Igs for human tissue antigens. Self-reactivity was observed in 26% of tumor Igs (25 of 98). For one follicular lymphoma patient, the recognized self-antigen was identified as myoferlin. This patient's tum ...[more]