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Toward the Atomic Structure of PrPSc.

ABSTRACT: In this review, we detail our current knowledge of PrPSc structure on the basis of structural and computational studies. We discuss the progress toward an atomic resolution description of PrPSc and results from the broader field of amyloid studies that may further inform our knowledge of this structure. Moreover, we summarize work that investigates the role of PrPSc structure in its toxicity, transmissibility, and species specificity. We look forward to an atomic model of PrPSc, which is expected to bring diagnostics and/or therapeutics to the field of prion disease.

SUBMITTER: Rodriguez JA 

PROVIDER: S-EPMC5585850 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Toward the Atomic Structure of PrP<sup>Sc</sup>.

Rodriguez Jose A JA   Jiang Lin L   Eisenberg David S DS  

Cold Spring Harbor perspectives in biology 20170901 9

In this review, we detail our current knowledge of PrP<sup>Sc</sup> structure on the basis of structural and computational studies. We discuss the progress toward an atomic resolution description of PrP<sup>Sc</sup> and results from the broader field of amyloid studies that may further inform our knowledge of this structure. Moreover, we summarize work that investigates the role of PrP<sup>Sc</sup> structure in its toxicity, transmissibility, and species specificity. We look forward to an atomic  ...[more]

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