Ontology highlight
ABSTRACT:
SUBMITTER: Wille H
PROVIDER: S-EPMC5874746 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Wille Holger H Requena Jesús R JR
Pathogens (Basel, Switzerland) 20180207 1
PrP<sup>Sc</sup> (scrapie isoform of the prion protein) prions are the infectious agent behind diseases such as Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy in cattle, chronic wasting disease in cervids (deer, elk, moose, and reindeer), as well as goat and sheep scrapie. PrP<sup>Sc</sup> is an alternatively folded variant of the cellular prion protein, PrP<sup>C</sup>, which is a regular, GPI-anchored protein that is present on the cell surface of neurons and other cell ...[more]