Ontology highlight
ABSTRACT:
SUBMITTER: Skaggs HS
PROVIDER: S-EPMC2266631 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Skaggs Hollie S HS Xing Hongyan H Wilkerson Donald C DC Murphy Lynea A LA Hong Yiling Y Mayhew Christopher N CN Sarge Kevin D KD
The Journal of biological chemistry 20070925 47
Stress conditions inhibit mRNA export, but mRNAs encoding heat shock proteins continue to be efficiently exported from the nucleus during stress. How HSP mRNAs bypass this stress-associated export inhibition was not known. Here, we show that HSF1, the transcription factor that binds HSP promoters after stress to induce their transcription, interacts with the nuclear pore-associating TPR protein in a stress-responsive manner. TPR is brought into proximity of the HSP70 promoter after stress and pr ...[more]