Ontology highlight
ABSTRACT:
SUBMITTER: Lee S
PROVIDER: S-EPMC5272179 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Lee Sungwoon S Rho Seung-Sik SS Park Hyojin H Park Jeong Ae JA Kim Jihye J Lee In-Kyu IK Koh Gou Young GY Mochizuki Naoki N Kim Young-Myeong YM Kwon Young-Guen YG
The Journal of clinical investigation 20161219 2
Controlled angiogenesis and lymphangiogenesis are essential for tissue development, function, and repair. However, aberrant neovascularization is an essential pathogenic mechanism in many human diseases, including diseases involving tumor growth and survival. Here, we have demonstrated that mice deficient in C-type lectin family 14 member A (CLEC14A) display enhanced angiogenic sprouting and hemorrhage as well as enlarged jugular lymph sacs and lymphatic vessels. CLEC14A formed a complex with VE ...[more]