Dataset Information

Childhood adiposity and fertility difficulties: the Bogalusa Heart Study.

ABSTRACT: BACKGROUND:Adult obesity is associated with infertility; however, childhood obesity has received little consideration. OBJECTIVES:The present study sought to evaluate the impact of childhood adiposity on fertility. METHODS:Associations between childhood adiposity and self-reported fertility difficulties were estimated among women participating in a long-term study of cardiovascular risks and reproductive health (n?=?1061). RESULTS:Participants with obesity between ages 9 and 12 were more likely to report fertility difficulties (adjusted relative risk [aRR], 1.82, 95% CI 1.17-2.82) and inability to become pregnant when trying (aRR?=?1.94, 95% CI 1.22-3.08) as were those with obesity prior to age 9 (aRR?=?1.76, 95% CI 1.04-2.97). Similar associations were seen among those ever overweight or obese in childhood. High subscapular skinfold thickness (age?

SUBMITTER: Jacobs MB

PROVIDER: S-EPMC5589511 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Childhood adiposity and fertility difficulties: the Bogalusa Heart Study.

Jacobs M B MB Bazzano L A LA Pridjian G G Harville E W EW

Pediatric obesity 20160628 6

<h4>Background</h4>Adult obesity is associated with infertility; however, childhood obesity has received little consideration.<h4>Objectives</h4>The present study sought to evaluate the impact of childhood adiposity on fertility.<h4>Methods</h4>Associations between childhood adiposity and self-reported fertility difficulties were estimated among women participating in a long-term study of cardiovascular risks and reproductive health (n = 1061).<h4>Results</h4>Participants with obesity between ag ...[more]

PMID: 27350648

Similar Datasets

Project description:Aims/hypothesisThe aim of this study was to characterise longitudinal profiles of BMI from childhood and to examine the impact of level-independent childhood BMI trajectories on adult type 2 diabetes.MethodsThe longitudinal cohort consisted of 2449 adults (1613 white and 836 black) who had their BMI measured between four and 15 times from childhood (4-19 years) to adulthood (20-51 years) and fasting glucose measured in adulthood. Model-estimated levels and linear slopes of BMI at childhood age points were calculated in 1-year intervals using growth-curve parameters and their first derivatives, respectively.ResultsBMI from childhood to adulthood fit cubic growth curves; linear and non-linear curve parameters differed significantly between race-sex groups. BMI showed race and sex differences from 15 years onwards. Individuals with hyperglycaemia had higher long-term BMI levels than those who were normoglycaemic in race-sex groups. Linear and non-linear slope parameters of BMI differed consistently and significantly between adult hyperglycaemia groups. The OR of childhood BMI levels for ages 4-19 years was 1.45-1.83 (p < 0.001 for all) for adult hyperglycaemia after adjustment for confounders. Level-adjusted linear slopes of BMI at ages 10-19 years showed significantly positive associations with adult hyperglycaemia (OR 1.17-1.50, p < 0.01 for all). The associations of childhood BMI linear slopes with adult hyperglycaemia were not significant during the age period 5-9 years. The trends in these associations were consistent across race-sex groups.Conclusions/interpretationThese observations indicate that childhood BMI trajectories have a significant impact on adult diabetes, independent of BMI levels. The adolescence age period is a crucial window for the development of diabetes in later life, which has implications for early-life prevention.Data availabilityAll data and materials are publicly available at the National Heart, Lung, and Blood Institute (NHLBI) Biologic Specimen and Data Repository and can be accessed at https://biolincc.nhlbi.nih.gov/studies/bhs .

Dataset Information

Childhood adiposity and fertility difficulties: the Bogalusa Heart Study.

Publications

Childhood adiposity and fertility difficulties: the Bogalusa Heart Study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets