Dataset Information

Childhood adiposity and fertility difficulties: the Bogalusa Heart Study.

ABSTRACT:

Background

Adult obesity is associated with infertility; however, childhood obesity has received little consideration.

Objectives

The present study sought to evaluate the impact of childhood adiposity on fertility.

Methods

Associations between childhood adiposity and self-reported fertility difficulties were estimated among women participating in a long-term study of cardiovascular risks and reproductive health (n = 1061).

Results

Participants with obesity between ages 9 and 12 were more likely to report fertility difficulties (adjusted relative risk [aRR], 1.82, 95% CI 1.17-2.82) and inability to become pregnant when trying (aRR = 1.94, 95% CI 1.22-3.08) as were those with obesity prior to age 9 (aRR = 1.76, 95% CI 1.04-2.97). Similar associations were seen among those ever overweight or obese in childhood. High subscapular skinfold thickness (age < 12) increased risk of receiving help becoming pregnant (aRR = 2.16, 95% CI 1.15-4.06), inability to become pregnant (aRR = 1.46, 95% CI 1.05-2.04) and any fertility difficulties (aRR = 1.56, 95% CI 1.13-2.14); associations for triceps skinfold were attenuated. Participants with increased adiposity also had fewer pregnancies and live births. Effects persisted, excluding women with polycystic ovarian syndrome.

Conclusions

This study supports an association between childhood adiposity and infertility, not solely driven by polycystic ovarian syndrome.

SUBMITTER: Jacobs MB

PROVIDER: S-EPMC5589511 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Publications

Childhood adiposity and fertility difficulties: the Bogalusa Heart Study.

Jacobs M B MB Bazzano L A LA Pridjian G G Harville E W EW

Pediatric obesity 20160628 6

<h4>Background</h4>Adult obesity is associated with infertility; however, childhood obesity has received little consideration.<h4>Objectives</h4>The present study sought to evaluate the impact of childhood adiposity on fertility.<h4>Methods</h4>Associations between childhood adiposity and self-reported fertility difficulties were estimated among women participating in a long-term study of cardiovascular risks and reproductive health (n = 1061).<h4>Results</h4>Participants with obesity between ag ...[more]

PMID: 27350648

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Project description:Aims/hypothesisThe aim of this study was to characterise longitudinal profiles of BMI from childhood and to examine the impact of level-independent childhood BMI trajectories on adult type 2 diabetes.MethodsThe longitudinal cohort consisted of 2449 adults (1613 white and 836 black) who had their BMI measured between four and 15 times from childhood (4-19 years) to adulthood (20-51 years) and fasting glucose measured in adulthood. Model-estimated levels and linear slopes of BMI at childhood age points were calculated in 1-year intervals using growth-curve parameters and their first derivatives, respectively.ResultsBMI from childhood to adulthood fit cubic growth curves; linear and non-linear curve parameters differed significantly between race-sex groups. BMI showed race and sex differences from 15 years onwards. Individuals with hyperglycaemia had higher long-term BMI levels than those who were normoglycaemic in race-sex groups. Linear and non-linear slope parameters of BMI differed consistently and significantly between adult hyperglycaemia groups. The OR of childhood BMI levels for ages 4-19 years was 1.45-1.83 (p < 0.001 for all) for adult hyperglycaemia after adjustment for confounders. Level-adjusted linear slopes of BMI at ages 10-19 years showed significantly positive associations with adult hyperglycaemia (OR 1.17-1.50, p < 0.01 for all). The associations of childhood BMI linear slopes with adult hyperglycaemia were not significant during the age period 5-9 years. The trends in these associations were consistent across race-sex groups.Conclusions/interpretationThese observations indicate that childhood BMI trajectories have a significant impact on adult diabetes, independent of BMI levels. The adolescence age period is a crucial window for the development of diabetes in later life, which has implications for early-life prevention.Data availabilityAll data and materials are publicly available at the National Heart, Lung, and Blood Institute (NHLBI) Biologic Specimen and Data Repository and can be accessed at https://biolincc.nhlbi.nih.gov/studies/bhs .

Dataset Information

Childhood adiposity and fertility difficulties: the Bogalusa Heart Study.

Background

Objectives

Methods

Results

Conclusions

Publications

Childhood adiposity and fertility difficulties: the Bogalusa Heart Study.

Similar Datasets

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