Ontology highlight
ABSTRACT:
SUBMITTER: Drienovska I
PROVIDER: S-EPMC5590542 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Chemical science 20141009 1
Artificial metalloenzymes have emerged as an attractive new approach to enantioselective catalysis. Herein, we introduce a novel strategy for preparation of artificial metalloenzymes utilizing amber stop codon suppression methodology for the <i>in vivo</i> incorporation of metal-binding unnatural amino acids. The resulting artificial metalloenzymes were applied in catalytic asymmetric Friedel-Crafts alkylation reactions and up to 83% ee for the product was achieved. ...[more]